"Bioeconomics provides a strategic advantage, because it provides a general, desirable, and worthwhile added benefit compared to conventional methods."
The Value of Bioeconomics
The basis of our Better Peptides Platform is a well engineered, multi-functional, and patented designer fusion protein for expression, protection, isolation, purification, and on-demand release of tailor-made linear and circular peptides. In other words, the BPP fusion protein comes with (almost) all molecular tools needed to clean itself.
Briefly, the BPP fusion protein consists of three noteworthy domains:
First, the Carrier & Binding (CB) Domain has a strong tendency to agglomerate in inclusion bodies when expressed in bacterial cultures (see advantages below). In addition, it exhibits a natural affinity to readily available and inexpensive biological purification matrixes allowing it to be purified in high yields (> 95%) using simple, reliable, and scalable chromatography processes. No hazardous solvents required!
Second, our Smart Release (SR) Domain (patent pending) exhibits an optimized pH-sensitive proteolytic activity that represents a well controlled release trigger of the final product. Most importantly, it releases the target linear or cyclic peptide or protein with authentic termini, i.e. there are no process related amino acid residues or elimination reactions.
Lastly, there is the Payload (P). The payload is your custom linear or cyclic peptides of 20 - 250 amino acid length. The possibilities are virtually limitless.
You already have a linear or cyclic peptide candidate that you would like to move into a flexible and scalable production pipeline? The Better Peptides Platform is probably the answer. Please contact us and we work together on a solution for your production needs.
In addition, we have a few promising peptide and protein candidates of our own, ready to be taken into culture and to be produced on demand.
