Figure | Representation and overview of BPP Technologies.
"Nature is nothing that needs to be overcome."
Functional bioactive peptides and proteins have an enormous but underutilised economical potential to improve the ecological balance in several major industry sectors producing or processing biological material, for instance, the agriculture, food, pharma or cosmetic sector.
For example, antimicrobial peptides can protect sensitive crop and/or temporarily prepare them naturally for climate change-related environmental impacts, such as droughts and pests, without the disadvantages of risking formation of resistence, hazardous residues and drift into adjacent soils or groundwater. Furthermore, in the production of vegan meat, the availability of protein-based growth factors plays a crucial role, and as flavour modulators, peptides can significantly reduce added sugars.
The problem? The availability!
The Better Peptides Platform, our award winning, proprietary core technology, allows us to manufacture virtually any complex linear or circular peptide of 15-150 amino acid length from simple harmless biological ingredients at industry relevant scales. From this unique capability alone, a multitude of opportunity arises that were never before thought to be possible. In only a few years since founding of the BPP GmbH, the platform has become an ecosystem. Major strifes have been made to further improve upon the technology and develop exciting new applications around it. Only recently, Bioportides were introduced with resounding feedback from laboratories that have tested it. Bioportides are a peptide-based transformation/transfection agents for nucleotide delivery and we are actively researching on exciting new ways to use our unique biotechnological peptide synthesis approach to solve pressing challenges in peptide candidate screening.
"Bioeconomics provides a strategic adantage, because it provides a general, desirable, and worthwhile added benefit compared to conventional methods."
The basis of our Better Peptides Platform is a well engineered, multi-functional, and patented designer fusion protein for expression, protection, isolation, purification, and on-demand release of tailor-made linear and circular peptides. In other words, the BPP fusion protein comes with (almost) all molecular tools needed to clean itself.
Briefly, the BPP fusion protein consists of three noteworthy domains:
First, the Carrier & Binding (CB) Domain has a strong tendency to agglomerate in inclusion bodies when expressed in bacterial cultures (see advantages below). In addition, it exhibits a natural affinity to readily available and inexpensive biological purification matrixes allowing it to be purified in high yields (> 95%) using simple, reliable, and scalable chromatography processes. No hazardous solvents required!
Second, our Smart Release (SR) Domain (patent pending) exhibits an optimized pH-sensitive proteolytic activity that represents a well controlled release trigger of the final product. Most importantly, it releases the target linear or cyclic peptide or protein with authentic termini, i.e. there are no process related amino acid residues or elimination reactions.
Lastly, there is the Payload (P). The payload is your custom linear or cyclic peptides of 20 - 250 amino acid length. The possibilities are virtually limitless.
You already have a linear or cyclic peptide candidate that you would like to move into a flexible and scalable production pipeline? The Better Peptides Platform is probably the answer. Please contact us and we work together on a solution for your production needs.
In addition, we have a few promising peptide and protein candidates of our own, ready to be taken into culture and to be produced on demand.
Figure | Bioeconomy Innovation Award 2023.
Badische Peptide und Proteine GmbH has won the Bioeconomy Innovation Award 2023 and was able to convince the attending entrepeneurs and bioscientists from numerous fields of research of its strategical advantages for a future-oriented biobased peptide-industry build from renewable biological resources.
BPP GmbH has filed several patent application (see below) describing its revolutionary innovative biotechnological process for the production of complex linear and cyclic peptides and small proteins (15 - 250 amino acids in size). Key features of the technology are that the process can produce any conceivable peptide sequence without production-related residues of relative high purity (> 95%) while being scalable up to the scale of tons. The complete elimination of highly specialised chemicals and the simplicity of product preparation further reduce production costs, which ultimately determine the economic viability of using peptide-based alternatives in agriculture and the food industry.
